A Possible Immune Reaction Producing Spontaneous Remission in Leukemia.

ONG PERIODS of latency, spontaneous remissions and nonsurgical “cures” in a variety of malignancies have stimulated speculation and expenimentation concerning immunity in cancer, a subject recently reviewed generally,1’2 and in reference to specific immune mechanisms3’4 of tumor inhibition and rejection. Acceptance of an immune theory in spontaneous cancer control demands demonstration of tumor-specific antigens, which has been accomplished in carcinogen-induced and transplanted tumors. Such direct evidence in spontaneous neoplasia is yet meagre, although differing